Sesamol reprograms mitochondrial dysfunction and metabolic signaling to rescue endothelial degeneration in Fuchs’ endothelial corneal dystrophy

Authors: Divyani Nayak, Ramaraj Kannan, Sharon D’Souza, Shivapriya Shivakumar, Rohit Shetty, Naren Shetty, Dipankar Malakar, Praveen Machiraju, Debashish Das, Arkasubhra Ghosh, Vrushali Deshpande, Koushik Chakrabarty

Keywords: Fuchs’ endothelial corneal dystrophy; Human cornea; Mitochondrial dysfunction; Oxidative stress; PPAR signaling; Sesamol; iPSC-derived corneal endothelium.

PMID: 42061480

DOI: 10.1016/j.freeradbiomed.2026.04.139