Dr Swaminathan
Talks about GROW-Ocular immunology

Ocular Immunology

Overview

Introduction

The eye maintains immune privilege through regulated immunomodulation that protects delicate tissues while preserving essential immune function. When this balance is disrupted, immune-mediated processes can drive inflammation and vision loss across a wide range of ocular diseases.

Ocular immunology research at Narayana Netralaya Foundation focuses on understanding eye-specific immune responses and how they differ from systemic immunity, enabling more precise and personalised approaches to diagnosis and treatment.

Why This Research Matters

Immune dysregulation contributes to inflammation-driven ocular damage.

Objectives

The Ocular Immunology programme aims to:

  • Understand Immune Responses In Ocular Disease
  • Identify Immunomodulatory Targets

Core Research Focus

Ocular immunology research investigates immune mechanisms that contribute to ocular inflammation and tissue damage.

Core areas of focus include:

  • Characterisation of innate and adaptive immune responses in ocular tissues
  • Identification of inflammatory mediators involved in retinal and corneal diseases
  • Study of immune-driven disease progression and tissue remodelling

The programme further focuses on:

  • Immune profiling using molecular and cellular assays
  • Understanding immune responses to therapeutic interventions
  • Identifying potential immunomodulatory strategies to limit disease progression

Together, these efforts support a diverse portfolio of ocular immunology research, with the assistance of researchers specializing in immunology and ocular pathology.

Team

The Ocular Immunology programme is led by a multidisciplinary team of scientists and clinician researchers with expertise in:

  • Researchers Specialising In Immunology
  • Ocular Pathology

Close collaboration between laboratory researchers and clinicians ensures that research priorities remain aligned with patient needs and real-world clinical applicability.

nVault - Publications | Articles | Research

Recent developments in gene therapy research in India

Recent developments in gene therapy research in India

Authors: Selot R, Ghosh A

Keywords: NA

PMID: 38384245

ITF2357 regulates NF-κB signaling pathway to protect barrier integrity in retinal pigment epithelial cells

ITF2357 regulates NF-κB signaling pathway to protect barrier integrity in retinal pigment epithelial cells

Authors: Rayne R Lim, Binapani Mahaling, Alison Tan, Milan Mehta, Charanjit Kaur , Walter Hunziker, Judy E Kim , Veluchamy A Barathi , Arkasubhra Ghosh , Shyam S Chaurasia

Keywords: NA

PMID: 38430220

DOI: 10.1096/fj.202301592R

Tear biomarkers in dry eye disease Progress in the last decade

Tear biomarkers in dry eye disease: Progress in the last decade.

Authors: Kumar NR, Praveen M, Narasimhan R, Khamar P, D’Souza S, Sinha-Roy A, Sethu S, Shetty R, Ghosh A

Keywords: NA

PMID: 37026250

DOI: 10.4103/IJO.IJO_2981_22

See All

Future Vision

The Ocular Immunology programme is progressing towards:

  • Advance understanding of immune mechanisms in ocular disease progression
  • Identify immune biomarkers for disease activity and treatment response
  • Support development of immunomodulatory therapeutic strategies
  • Integrate immune insights with gene, cell, and drug-based therapies
  • Improve long term outcomes through immuneaware intervention approaches