Dr Swaminathan
Talks about GROW-Ocular immunology

Ocular Immunology

Overview

Introduction

The eye maintains immune privilege through regulated immunomodulation that protects delicate tissues while preserving essential immune function. When this balance is disrupted, immune-mediated processes can drive inflammation and vision loss across a wide range of ocular diseases.

Ocular immunology research at Narayana Netralaya Foundation focuses on understanding eye-specific immune responses and how they differ from systemic immunity, enabling more precise and personalised approaches to diagnosis and treatment.

Why This Research Matters

Immune dysregulation contributes to inflammation-driven ocular damage.

Objectives

The Ocular Immunology programme aims to:

  • Understand Immune Responses In Ocular Disease
  • Identify Immunomodulatory Targets

Core Research Focus

Ocular immunology research investigates immune mechanisms that contribute to ocular inflammation and tissue damage.

Core areas of focus include:

  • Characterisation of innate and adaptive immune responses in ocular tissues
  • Identification of inflammatory mediators involved in retinal and corneal diseases
  • Study of immune-driven disease progression and tissue remodelling

The programme further focuses on:

  • Immune profiling using molecular and cellular assays
  • Understanding immune responses to therapeutic interventions
  • Identifying potential immunomodulatory strategies to limit disease progression

Together, these efforts support a diverse portfolio of ocular immunology research, with the assistance of researchers specializing in immunology and ocular pathology.

Team

The Ocular Immunology programme is led by a multidisciplinary team of scientists and clinician researchers with expertise in:

  • Researchers Specialising In Immunology
  • Ocular Pathology

Close collaboration between laboratory researchers and clinicians ensures that research priorities remain aligned with patient needs and real-world clinical applicability.

nVault - Publications | Articles | Research

New Project - 2026-03-28T013910.165

Distinct relationships between secreted factors measured in matched tear fluid, aqueous, vitreous, and plasma samples from patients with retinal conditions

Authors: Tanuja Arun Vaidya, Chaitra Jayadev, Archana Padmanabhan Nair, Ramaraj Kannan, Santhosh Gopi, Krishna Gadde, Thirumalesh Mochi Basavaraj, Naren Shetty, Rohit Shetty, Arkasubhra Ghosh, Swaminathan Sethu

Keywords: Angiogenic factors; Aqueous humor; Biomarkers; Inflammatory factors; Plasma; Tear fluid; Vitreous humor.

PMID: 40713973

DOI: 10.1016/j.exer.2025.110538

Management of Ocular Neuropathic Pain With Vitamin B12 Supplements A Case Report

Management of Ocular Neuropathic Pain With Vitamin B12 Supplements: A Case Report

Authors: Rohit Shetty, Kalyani Deshpande, Arkasubhra Ghosh, Swaminathan Sethu

Keywords: NA

PMID: 26266431

DOI: 10.1097/ICO.0000000000000572

Vision Crisis-Bilateral Outer Retinitis Due to Mumps Virus

Vision Crisis-Bilateral Outer Retinitis Due to Mumps Virus

Authors: Radhika Sriram, Swaminathan Sethu , Arkasubhra Ghosh , Rohit Shetty , Sara Rizvi , Namita Dave , Ria Sabrene Fernandes, Aradhya Bagchi, Ankush Kawali, Sai Bhakti Mishra , Padmamalini Mahendradas

Keywords: NA

PMID: 39116409

DOI: 10.1080/09273948.2024.2382925

See All

Future Vision

The Ocular Immunology programme is progressing towards:

  • Advance understanding of immune mechanisms in ocular disease progression
  • Identify immune biomarkers for disease activity and treatment response
  • Support development of immunomodulatory therapeutic strategies
  • Integrate immune insights with gene, cell, and drug-based therapies
  • Improve long term outcomes through immuneaware intervention approaches