Dr Swaminathan
Talks about GROW-Ocular immunology

Ocular Immunology

Overview

Introduction

The eye maintains immune privilege through regulated immunomodulation that protects delicate tissues while preserving essential immune function. When this balance is disrupted, immune-mediated processes can drive inflammation and vision loss across a wide range of ocular diseases.

Ocular immunology research at Narayana Netralaya Foundation focuses on understanding eye-specific immune responses and how they differ from systemic immunity, enabling more precise and personalised approaches to diagnosis and treatment.

Why This Research Matters

Immune dysregulation contributes to inflammation-driven ocular damage.

Objectives

The Ocular Immunology programme aims to:

  • Understand Immune Responses In Ocular Disease
  • Identify Immunomodulatory Targets

Core Research Focus

Ocular immunology research investigates immune mechanisms that contribute to ocular inflammation and tissue damage.

Core areas of focus include:

  • Characterisation of innate and adaptive immune responses in ocular tissues
  • Identification of inflammatory mediators involved in retinal and corneal diseases
  • Study of immune-driven disease progression and tissue remodelling

The programme further focuses on:

  • Immune profiling using molecular and cellular assays
  • Understanding immune responses to therapeutic interventions
  • Identifying potential immunomodulatory strategies to limit disease progression

Together, these efforts support a diverse portfolio of ocular immunology research, with the assistance of researchers specializing in immunology and ocular pathology.

Team

The Ocular Immunology programme is led by a multidisciplinary team of scientists and clinician researchers with expertise in:

  • Researchers Specialising In Immunology
  • Ocular Pathology

Close collaboration between laboratory researchers and clinicians ensures that research priorities remain aligned with patient needs and real-world clinical applicability.

nVault - Publications | Articles | Research

Multimodal Imaging in Unilateral Acute Idiopathic Maculopathy with Staphylococcus aureus Infection

Multimodal Imaging in Unilateral Acute Idiopathic Maculopathy with Staphylococcus aureus Infection

Authors: Padmamalini Mahendradas, Aditya Patil, Rahul Patil, Raghav Narasimhan, Radhika Sriram, Sai Bhakti Mishra, Ankush Kawali, Poornachandra Gowda, Rohit Shetty, Abhijit Sinha Roy

Keywords: NA

PMID: 39561034

DOI: 10.1080/09273948.2024.2425976

An objective assessment of vision performance at different reading distances after smooth incision lenticular keratomileusis (SILK) for myopia

An objective assessment of vision performance at different reading distances after smooth incision lenticular keratomileusis (SILK) for myopia

Authors: Rohit Shetty, Pooja Khamar, Raghav Narasimhan, Ritika Mullick, Anushree Bhatkal, Anisha Ramesh & Abhijit Sinha Roy

Keywords: NA

PMID: 40781520

DOI: 10.1038/s41598-025-13957-6

Attenuated adenosine mediated immune-dampening increases natural killer cell activity in early age-related macular degeneration

Attenuated adenosine mediated immune-dampening increases natural killer cell activity in early age-related macular degeneration

Authors: Archana Padmanabhan Nair, Sayan Ghosh, Vishnu Suresh Babu, Machiraju Praveen, Ying Xin, Ganesh Ram Sahu, Tanuja Arun Vaidya, Jayasree Debnath, Karthik Raja, Santhosh Gopi Krishna Gadde, Thirumalesh M B, Naren Shetty, Aishwarya Saxena, Rohit Shetty, Stacey Hose, Vrushali Deshpande, Koushik Chakrabarty, James T Handa, J Jiang Qian, Swaminathan Sethu, Debasish Sinha, Arkasubhra Ghosh

Keywords: NA

PMID: 39975064

DOI: 10.1101/2025.01.22.634301

See All

Future Vision

The Ocular Immunology programme is progressing towards:

  • Advance understanding of immune mechanisms in ocular disease progression
  • Identify immune biomarkers for disease activity and treatment response
  • Support development of immunomodulatory therapeutic strategies
  • Integrate immune insights with gene, cell, and drug-based therapies
  • Improve long term outcomes through immuneaware intervention approaches