Dr Nallathambi
Talks about GROW-Molecular signaling

Dr. Debashish
Specialty Eye Care Research Lab

Molecular Signaling

Overview

Introduction

Molecular signaling research studies the pathways that regulate cellular behaviour in health and disease.

Why This Research Matters

Understanding signaling pathways provides insights into disease mechanisms and therapeutic targets.

Objectives

The Molecular Signaling programme aims to:

  • Decode Disease-Associated Signaling Pathways
  • Identify molecular targets for intervention

Core Research Focus

Molecular signaling research focuses on understanding the intracellular pathways that govern cellular behaviour in ocular health and disease.

 

Core areas of focus include:

  • Identification of dysregulated signaling pathways in retinal and corneal diseases
  • Study of cell survival, stress response, inflammation, and degeneration pathways
  • Investigation of cross-talk between genetic, metabolic, and immune signaling networks

The programme also emphasises:

  • Linking signaling alterations to functional and structural disease outcomes
  • Identifying molecular nodes that can serve as a therapeutic target
  • Supporting downstream gene, drug, or biologic-based intervention strategies

Together, these efforts support a diverse portfolio of Molecular Signaling research, spanning various areas cell biology, molecular signaling, and disease modelling.

Team

The Molecular Signaling programme is led by a multidisciplinary team of scientists and clinician-researchers with expertise in:

  • Cell Biology
  • Molecular Signaling
  • Disease Modelling

Close collaboration between laboratory researchers and clinicians ensures that research priorities remain aligned with patient needs and real-world clinical applicability.

nVault - Publications | Articles | Research

Recent developments in gene therapy research in India

Recent developments in gene therapy research in India

Authors: Selot R, Ghosh A

Keywords: NA

PMID: 38384245

ITF2357 regulates NF-κB signaling pathway to protect barrier integrity in retinal pigment epithelial cells

ITF2357 regulates NF-κB signaling pathway to protect barrier integrity in retinal pigment epithelial cells

Authors: Rayne R Lim, Binapani Mahaling, Alison Tan, Milan Mehta, Charanjit Kaur , Walter Hunziker, Judy E Kim , Veluchamy A Barathi , Arkasubhra Ghosh , Shyam S Chaurasia

Keywords: NA

PMID: 38430220

DOI: 10.1096/fj.202301592R

Attenuated adenosine mediated immune-dampening increases natural killer cell activity in early age-related macular degeneration

Attenuated adenosine mediated immune-dampening increases natural killer cell activity in early age-related macular degeneration

Authors: Archana Padmanabhan Nair, Sayan Ghosh, Vishnu Suresh Babu, Machiraju Praveen, Ying Xin, Ganesh Ram Sahu, Tanuja Arun Vaidya, Jayasree Debnath, Karthik Raja, Santhosh Gopi Krishna Gadde, Thirumalesh M B, Naren Shetty, Aishwarya Saxena, Rohit Shetty, Stacey Hose, Vrushali Deshpande, Koushik Chakrabarty, James T Handa, J Jiang Qian, Swaminathan Sethu, Debasish Sinha, Arkasubhra Ghosh

Keywords: NA

PMID: 39975064

DOI: 10.1101/2025.01.22.634301

See All

Future Vision

The Molecular Signaling programme is progressing towards:

  • Deepen understanding of disease-driving signaling pathways
  • Identify actionable molecular targets for therapeutic intervention
  • Support targeted drug and biologic development efforts
  • Strengthen links between signaling insights and translational research programmes
  • Enable cross-pathway integration across genetic, metabolic, and immune research