Dr Nallathambi
Talks about GROW-Molecular signaling

Dr. Debashish
Specialty Eye Care Research Lab

Molecular Signaling

Overview

Introduction

Molecular signaling research studies the pathways that regulate cellular behaviour in health and disease.

Why This Research Matters

Understanding signaling pathways provides insights into disease mechanisms and therapeutic targets.

Objectives

The Molecular Signaling programme aims to:

  • Decode Disease-Associated Signaling Pathways
  • Identify molecular targets for intervention

Core Research Focus

Molecular signaling research focuses on understanding the intracellular pathways that govern cellular behaviour in ocular health and disease.

 

Core areas of focus include:

  • Identification of dysregulated signaling pathways in retinal and corneal diseases
  • Study of cell survival, stress response, inflammation, and degeneration pathways
  • Investigation of cross-talk between genetic, metabolic, and immune signaling networks

The programme also emphasises:

  • Linking signaling alterations to functional and structural disease outcomes
  • Identifying molecular nodes that can serve as a therapeutic target
  • Supporting downstream gene, drug, or biologic-based intervention strategies

Together, these efforts support a diverse portfolio of Molecular Signaling research, spanning various areas cell biology, molecular signaling, and disease modelling.

Team

The Molecular Signaling programme is led by a multidisciplinary team of scientists and clinician-researchers with expertise in:

  • Cell Biology
  • Molecular Signaling
  • Disease Modelling

Close collaboration between laboratory researchers and clinicians ensures that research priorities remain aligned with patient needs and real-world clinical applicability.

nVault - Publications | Articles | Research

Comparative transcriptomic analysis of retinal response to diverse cellular stresses reveals relative contributions of different cell death processes and signalling networks

Comparative transcriptomic analysis of retinal response to diverse cellular stresses reveals relative contributions of different cell death processes and signalling networks

Authors: Subhradeep Sarkar, Ramaraj Kannan, Trailokyanath Panigrahi, Karthickraja Veeramani, Thirumalesh Mb, Shom Shanker Bhattacharya, Arkasubhra Ghosh

Keywords: NA

PMID: 41326361

DOI: 10.1038/s41419-025-08257-w

The potential implications of dysregulated DNA damage repair genes and their modulators as adjuvants for current chemotherapy regimens in Retinoblastoma tumors

The potential implications of dysregulated DNA damage repair genes and their modulators as adjuvants for current chemotherapy regimens in Retinoblastoma tumors

Authors: Keya Katare, Rohit Shetty, Arkasubhra Ghosh

Keywords: NA

PMID: 41386960

DOI: 10.1016/j.mrgentox.2025.503903

New Project - 2026-03-28T013910.165

Distinct relationships between secreted factors measured in matched tear fluid, aqueous, vitreous, and plasma samples from patients with retinal conditions

Authors: Tanuja Arun Vaidya, Chaitra Jayadev, Archana Padmanabhan Nair, Ramaraj Kannan, Santhosh Gopi, Krishna Gadde, Thirumalesh Mochi Basavaraj, Naren Shetty, Rohit Shetty, Arkasubhra Ghosh, Swaminathan Sethu

Keywords: Angiogenic factors; Aqueous humor; Biomarkers; Inflammatory factors; Plasma; Tear fluid; Vitreous humor.

PMID: 40713973

DOI: 10.1016/j.exer.2025.110538

See All

Future Vision

The Molecular Signaling programme is progressing towards:

  • Deepen understanding of disease-driving signaling pathways
  • Identify actionable molecular targets for therapeutic intervention
  • Support targeted drug and biologic development efforts
  • Strengthen links between signaling insights and translational research programmes
  • Enable cross-pathway integration across genetic, metabolic, and immune research