Dr Vrushali Deshpande
Talks about GROW-Proteomics and Metabolomics

Proteomics & Metabolomics

Overview

Introduction

Proteomics and metabolomics research focus on understanding disease through large-scale profiling of proteins and metabolites. At NNF, this work aims to identify molecular signatures that reflect disease onset and progression.

Why This Research Matters

Molecular biomarkers can enable early diagnosis, prognosis, and personalised treatment strategies.

Objectives

The Proteomics & Metabolomics programme aims to:

  • Identify Disease-Associated Biomarkers
  • Develop molecular diagnostic tools
  • Integrate molecular data with clinical outcomes

Core Research Focus

The proteomics and metabolomics programme aims to decode disease biology through large-scale molecular profiling of ocular fluids and tissues.

 

Core areas of focus include:

  • Comprehensive protein and metabolite profiling of tear, aqueous humour, vitreous, and serum samples
  • Identification of disease-associated molecular signatures and pathways
  • Comparative profiling across disease stages and treatment responses

Key technical and analytical focus areas include:

  • Mass spectrometry–based discovery and targeted validation pipelines
  • Integration of proteomic and metabolomic datasets with clinical phenotypes
  • Pathway-level analysis to uncover mechanisms of disease progression

Together, these efforts support a diverse portfolio of Proteomics & Metabolomics research, spanning various areas mass spectrometry, molecular biology, bioinformatics, and clinical research.

Team

The Proteomics & Metabolomics programme is led by a multidisciplinary team of scientists and clinician-researchers with expertise in:

  • Mass Spectrometry
  • Molecular Biology
  • Bioinformatics
  • Clinical Research

Close collaboration between laboratory researchers and clinicians ensures that research priorities remain aligned with patient needs and real-world clinical applicability.

nVault - Publications | Articles | Research

Sesamol reprograms mitochondrial dysfunction and metabolic signaling to rescue endothelial degeneration in Fuchs' endothelial corneal dystrophy

Sesamol reprograms mitochondrial dysfunction and metabolic signaling to rescue endothelial degeneration in Fuchs’ endothelial corneal dystrophy

Authors: Divyani Nayak, Ramaraj Kannan, Sharon D’Souza, Shivapriya Shivakumar, Rohit Shetty, Naren Shetty, Dipankar Malakar, Praveen Machiraju, Debashish Das, Arkasubhra Ghosh, Vrushali Deshpande, Koushik Chakrabarty

Keywords: Fuchs’ endothelial corneal dystrophy; Human cornea; Mitochondrial dysfunction; Oxidative stress; PPAR signaling; Sesamol; iPSC-derived corneal endothelium.

PMID: 42061480

DOI: 10.1016/j.freeradbiomed.2026.04.139

New Project - 2026-03-28T013910.165

Distinct relationships between secreted factors measured in matched tear fluid, aqueous, vitreous, and plasma samples from patients with retinal conditions

Authors: Tanuja Arun Vaidya, Chaitra Jayadev, Archana Padmanabhan Nair, Ramaraj Kannan, Santhosh Gopi, Krishna Gadde, Thirumalesh Mochi Basavaraj, Naren Shetty, Rohit Shetty, Arkasubhra Ghosh, Swaminathan Sethu

Keywords: Angiogenic factors; Aqueous humor; Biomarkers; Inflammatory factors; Plasma; Tear fluid; Vitreous humor.

PMID: 40713973

DOI: 10.1016/j.exer.2025.110538

Management of Ocular Neuropathic Pain With Vitamin B12 Supplements A Case Report

Management of Ocular Neuropathic Pain With Vitamin B12 Supplements: A Case Report

Authors: Rohit Shetty, Kalyani Deshpande, Arkasubhra Ghosh, Swaminathan Sethu

Keywords: NA

PMID: 26266431

DOI: 10.1097/ICO.0000000000000572

See All

Future Vision

The Proteomics & Metabolomics programme is progressing towards:

  • Translate molecular signatures into clinically actionable biomarkers
  • Validate biomarker panels across larger and diverse patient cohorts
  • Integrate molecular data with imaging and genetic information for precision diagnostics
  • Support development of diagnostic and prognostic clinical tools
  • Enable disease stratification to inform personalised treatment strategies