Dr Vrushali Deshpande
Talks about GROW-Proteomics and Metabolomics

Proteomics & Metabolomics

Overview

Introduction

Proteomics and metabolomics research focus on understanding disease through large-scale profiling of proteins and metabolites. At NNF, this work aims to identify molecular signatures that reflect disease onset and progression.

Why This Research Matters

Molecular biomarkers can enable early diagnosis, prognosis, and personalised treatment strategies.

Objectives

The Proteomics & Metabolomics programme aims to:

  • Identify Disease-Associated Biomarkers
  • Develop molecular diagnostic tools
  • Integrate molecular data with clinical outcomes

Core Research Focus

The proteomics and metabolomics programme aims to decode disease biology through large-scale molecular profiling of ocular fluids and tissues.

 

Core areas of focus include:

  • Comprehensive protein and metabolite profiling of tear, aqueous humour, vitreous, and serum samples
  • Identification of disease-associated molecular signatures and pathways
  • Comparative profiling across disease stages and treatment responses

Key technical and analytical focus areas include:

  • Mass spectrometry–based discovery and targeted validation pipelines
  • Integration of proteomic and metabolomic datasets with clinical phenotypes
  • Pathway-level analysis to uncover mechanisms of disease progression

Together, these efforts support a diverse portfolio of Proteomics & Metabolomics research, spanning various areas mass spectrometry, molecular biology, bioinformatics, and clinical research.

Team

The Proteomics & Metabolomics programme is led by a multidisciplinary team of scientists and clinician-researchers with expertise in:

  • Mass Spectrometry
  • Molecular Biology
  • Bioinformatics
  • Clinical Research

Close collaboration between laboratory researchers and clinicians ensures that research priorities remain aligned with patient needs and real-world clinical applicability.

nVault - Publications | Articles | Research

Multimodal Imaging in Unilateral Acute Idiopathic Maculopathy with Staphylococcus aureus Infection

Multimodal Imaging in Unilateral Acute Idiopathic Maculopathy with Staphylococcus aureus Infection

Authors: Padmamalini Mahendradas, Aditya Patil, Rahul Patil, Raghav Narasimhan, Radhika Sriram, Sai Bhakti Mishra, Ankush Kawali, Poornachandra Gowda, Rohit Shetty, Abhijit Sinha Roy

Keywords: NA

PMID: 39561034

DOI: 10.1080/09273948.2024.2425976

An objective assessment of vision performance at different reading distances after smooth incision lenticular keratomileusis (SILK) for myopia

An objective assessment of vision performance at different reading distances after smooth incision lenticular keratomileusis (SILK) for myopia

Authors: Rohit Shetty, Pooja Khamar, Raghav Narasimhan, Ritika Mullick, Anushree Bhatkal, Anisha Ramesh & Abhijit Sinha Roy

Keywords: NA

PMID: 40781520

DOI: 10.1038/s41598-025-13957-6

New Project - 2026-03-28T215011.833

Lower Levels of Endogenous Intraocular Interferon Beta in Patients with Primary Glaucoma

Authors: Archana Padmanabhan Nair, Praveen Machiraju, Sushma Tejwani, Shoruba Dinakaran, Sathi Devi A V, Naren Shetty, Rohit Shetty, Arkasubhra Ghosh, Swaminathan Sethu

Keywords: IFN-β; aqueous humor; glaucoma; interferon beta; trabecular meshwork

PMID: 40485295

DOI: 10.1089/jop.2025.0085

See All

Future Vision

The Proteomics & Metabolomics programme is progressing towards:

  • Translate molecular signatures into clinically actionable biomarkers
  • Validate biomarker panels across larger and diverse patient cohorts
  • Integrate molecular data with imaging and genetic information for precision diagnostics
  • Support development of diagnostic and prognostic clinical tools
  • Enable disease stratification to inform personalised treatment strategies