Dr. Ruchita Selot tells you about our Non Ocular Disease research

Non Ocular Disease

Overview

Introduction

The Non Ocular Disease programme applies core biological and analytical expertise developed in ophthalmic research to systemic diseases. By leveraging genomics, multiomics, and cellular models, the programme explores disease mechanisms beyond the eye.

This work enables cross-disciplinary insights and extends the translational impact of research platforms developed at the GROW Lab.

Why This Research Matters

Shared molecular mechanisms allow ocular research tools to inform broader disease understanding.

Objectives

The Non Ocular Disease programme aims to:

  • Extend Research Platforms Beyond Ophthalmology
  • Atherosclerosis
  • Diabetes
  • Duchenne Muscular Dystrophy
  • Sickle Cell Anemia
  • FENIB

Core Research Focus

The non-ocular disease programme applies core biological and analytical platforms developed at NNF to systemic and non-eye related diseases.

 

Core areas of focus include:

  • Application of genomics, proteomics, and cellular models to systemic conditions
  • Cross-disease analysis to identify shared molecular mechanisms
  • Translational research that leverages ocular platforms for broader biomedical questions

This work enables:

  • Methodological integration of ocular and non-ocular research
  • Expansion of institutional research impact beyond ophthalmology

Together, these efforts support a diverse portfolio of Non Ocular Disease research, spanning various areas Cross-domain research scientists.

Team

The Non Ocular Disease programme is led by a multidisciplinary team of scientists and clinician researchers with expertise in:

  • Cross-Domain Research Scientists

Close collaboration between laboratory researchers and clinicians ensures that research priorities remain aligned with patient needs and real-world clinical applicability.

nVault - Publications | Articles | Research

Recent developments in gene therapy research in India

Recent developments in gene therapy research in India

Authors: Selot R, Ghosh A

Keywords: NA

PMID: 38384245

ITF2357 regulates NF-κB signaling pathway to protect barrier integrity in retinal pigment epithelial cells

ITF2357 regulates NF-κB signaling pathway to protect barrier integrity in retinal pigment epithelial cells

Authors: Rayne R Lim, Binapani Mahaling, Alison Tan, Milan Mehta, Charanjit Kaur , Walter Hunziker, Judy E Kim , Veluchamy A Barathi , Arkasubhra Ghosh , Shyam S Chaurasia

Keywords: NA

PMID: 38430220

DOI: 10.1096/fj.202301592R

New Project - 2026-03-28T013910.165

Distinct relationships between secreted factors measured in matched tear fluid, aqueous, vitreous, and plasma samples from patients with retinal conditions

Authors: Tanuja Arun Vaidya, Chaitra Jayadev, Archana Padmanabhan Nair, Ramaraj Kannan, Santhosh Gopi, Krishna Gadde, Thirumalesh Mochi Basavaraj, Naren Shetty, Rohit Shetty, Arkasubhra Ghosh, Swaminathan Sethu

Keywords: Angiogenic factors; Aqueous humor; Biomarkers; Inflammatory factors; Plasma; Tear fluid; Vitreous humor.

PMID: 40713973

DOI: 10.1016/j.exer.2025.110538

See All

Future Vision

The Non Ocular Disease programme is progressing towards:

  • Extend core research platforms to systemic and non-ocular diseases
  • Foster cross-disciplinary collaboration beyond ophthalmology
  • Apply molecular and cellular tools to broader biomedical questions
  • Strengthen translational research impact across disease domains
  • Enable methodological innovation through cross-disease knowledge transfer